Rhodopeptins (Mer-N1033), novel cyclic tetrapeptides with antifungal activity from Rhodococcus sp.: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

被引：42

作者：

Chiba, H

Agematu, H

Kaneto, R

Terasawa, T

Sakai, K

Dobashi, K

Yoshioka, T

机构：

[1] Mercian Corp, Proc Dev Labs, Shizuoka 4380078, Japan

[2] Mercian Corp, Cent Res Labs, Fujisawa, Kanagawa 2510057, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 08期

关键词：

D O I：

10.7164/antibiotics.52.695

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five novel cyclic tetrapeptides, named rhodopeptin C1, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a beta-amino acid and three usual alpha-aminoacids. Rhodopeptins show high in vitro antifungal activity against Candida albicans and Crytococcus neoformans, whereas they show no activity against bacteria..

引用

页码：695 / 699

页数：5

共 14 条

[1]

[Anonymous], 1989, BERGYS MANUAL SYSTEM

[2] METABOLIC PRODUCTS OF MICROORGANISM .143. ECHINOCANDIN B, A NEW POLYPEPTIDE ANTIBIOTIC FROM ASPERGILLUS NIDULANS VAR ECHINULATUS - ISOLATION AND BUILDING UNITS [J].