Two sets of human-tropic pig retrovirus

被引：338

作者：

LeTissier, P ^{[1
]}

Stoye, JP ^{[1
]}

Takeuchi, Y ^{[1
]}

Patience, C ^{[1
]}

Weiss, RA ^{[1
]}

机构：

[1] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

来源：

NATURE | 1997年 / 389卷 / 6652期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/39489

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Advances in controlling immunological rejection have raised the possibility that pigs could be used as a source of organs and tissues for transplantation into humans1,2. However, the report that one pig kidney cell line, PK15, produces Ctype retroviruses capable of infecting human cells3 has reinforced fears over the potential risks of viral infections associated with xenotransplantation4,5. Further support for these fears comes from the discovery of two different classes of porcine endogenous proviruses (PERVs), capable of infecting human cells, in PK15 cells as well as in a variety of normal porcine tissues.

引用

页码：681 / 682

页数：2

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