Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling

被引：43

作者：

Fujiwara, Yukio ^{[1
]}

Takaishi, Kiyomi ^{[1
,2
]}

Nakao, Junko ^{[1
,2
]}

Ikeda, Tsuyoshi ^{[3
]}

Katabuchi, Hidetaka ^{[2
]}

Takeya, Motohiro ^{[1
]}

Komohara, Yoshihiro ^{[1
]}

机构：

[1] Kumamoto Univ, Dept Cell Pathol, Grad Sch Med Sci, Kumamoto 8608556, Japan

[2] Kumamoto Univ, Dept Obstet & Gynecol, Grad Sch Med Sci, Kumamoto 8608556, Japan

[3] Sojo Univ, Dept Nat Med, Fac Pharmaceut Sci, Kumamoto 8600082, Japan

来源：

ONCOLOGY LETTERS | 2013年 / 6卷 / 06期

关键词：

macrophage; signal transducer and activator of transcription 3; ovarian cancer; corosolic acid; TUMOR PROGRESSION; CELLS; MACROPHAGES; STAT3; INFLAMMATION; INVOLVEMENT;

D O I：

10.3892/ol.2013.1591

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects.

引用

页码：1619 / 1623

页数：5

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