Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression

被引：41

作者：

Hong, Wu ^{[1
]}

Fan, Jinbo ^{[3
]}

Yuan, Chengmei ^{[1
]}

Zhang, Chen ^{[1
,2
]}

Hu, Yingyan ^{[1
]}

Peng, Daihui ^{[1
]}

Wang, Yong ^{[1
]}

Huang, Jia ^{[1
]}

Li, Zezhi ^{[1
]}

Yu, Shunying ^{[1
]}

Liu, Xiaohua ^{[1
]}

Wu, Zhiguo ^{[1
]}

Chen, Jun ^{[1
]}

Yi, Zhenghui ^{[1
]}

Xu, Lin ^{[2
]}

Fang, Yiru ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming, Peoples R China

[3] Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

来源：

NEUROREPORT | 2014年 / 25卷 / 10期

基金：

中国国家自然科学基金;

关键词：

brain-derived neurotrophin factor; mitogen-activated protein kinase kinase 1; treatment-resistant depression; treatment-responsive depression; NEUROTROPHIC FACTOR BDNF; MAJOR DEPRESSION; VAL66MET POLYMORPHISM; SUICIDE VICTIMS; DISORDER MDD; SERUM-LEVELS; PLASMA BDNF; BRAIN; MULTICENTER; EXPRESSION;

D O I：

10.1097/WNR.0000000000000165

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The aim of the current study was to investigate whether the levels of mRNA expression of brain-derived neurotrophin factor (BDNF) and a related gene MEK1 were more obviously decreased in treatment-resistant depression (TRD). In total, 50 patients with major depressive disorder (including 26 with TRD and 24 with treatment-responsive depression) and 48 healthy controls were enrolled. BDNF and MEK1 mRNA levels in blood samples from all patients and controls were measured using reverse transcriptase-PCR. BDNF and MEK1 mRNA levels were significantly reduced in patients with major depressive disorder when compared with healthy controls (BDNF: P<0.01; MEK1: P<0.001), as well as among treatment-resistant depressive patients as compared with treatment-responsive depressive patients (BDNF: P<0.001; MEK1: P<0.01). Our findings support the hypothesis that BDNF and MEK1 mRNA expression levels are more obviously decreased in patients with TRD.

引用

页码：753 / 755

页数：3

共 19 条

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