Genetics: A touch of elegance with RNAi

被引：63

作者：

Hunter, CP ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(99)80276-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA-mediated gene interference (RNAi), a rapid, convenient tool for inhibiting gene function in Caenorhabditis elegans, has recently been shown to work in other organisms. (C) Elsevier Science Ltd ISSN 0960-9822.

引用

页码：R440 / R442

页数：3

共 20 条

[1] Double-stranded RNA specifically disrupts gene expression during planarian regeneration [J].

Alvarado, AS ;

Newmark, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5049-5054

[2] Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity [J].

Bhat, MA ;

Izaddoost, S ;

Lu, Y ;

Cho, KO ;

Choi, KW ;

Bellen, HJ .

CELL, 1999, 96 (06) :833-845

[3]

CLARK SG, 1994, GENETICS, V137, P987

[4] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[5] PAR-1, A GENE REQUIRED FOR ESTABLISHING POLARITY IN C-ELEGANS EMBRYOS, ENCODES A PUTATIVE SER/THR KINASE THAT IS ASYMMETRICALLY DISTRIBUTED [J].

GUO, S ;

KEMPHUES, KJ .

CELL, 1995, 81 (04) :611-620

[6] A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans [J].

Guo, S ;

Kemphues, KJ .

NATURE, 1996, 382 (6590) :455-458

[7] THE LIN-15 LOCUS ENCODES 2 NEGATIVE REGULATORS OF CAENORHABDITIS-ELEGANS VULVAR DEVELOPMENT [J].

HUANG, LS ;

TZOU, P ;

STERNBERG, PW .

MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (04) :395-411

[8] Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C-elegans embryos [J].

Hunter, CP ;

Kenyon, C .

CELL, 1996, 87 (02) :217-226

[9] Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway [J].

Kennerdell, JR ;

Carthew, RW .

CELL, 1998, 95 (07) :1017-1026

[10] Targeted disruption of gene function in Drosophila by RNA interference (RNA-i):: A role for nautilus in embryonic somatic muscle formation [J].

Misquitta, L ;

Paterson, BM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1451-1456

← 1 2 →