DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

被引：578

作者：

Cadet, Jean ^{[1
,2
]}

Wagner, J. Richard ^{[2
]}

机构：

[1] CEA Grenoble, Inst Nanosci & Cryogenie, Direct Sci Mat, F-38054 Grenoble, France

[2] Univ Sherbrooke, Fac Med & Sci Sante, Dept Med Nucl & Radiobiol, Sherbrooke, PQ J1H 5N4, Canada

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2013年 / 5卷 / 02期

关键词：

CYCLOBUTANE PYRIMIDINE DIMERS; PERFORMANCE LIQUID-CHROMATOGRAPHY; OXIDATIVELY GENERATED DAMAGE; HYPOCHLORITE-INDUCED DAMAGE; TANDEM MASS-SPECTROMETRY; CROSS-LINK FORMATION; HO-CENTER-DOT; CELLULAR-DNA; HUMAN SKIN; GUANINE OXIDATION;

D O I：

10.1101/cshperspect.a012559

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey. This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5',8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron oxidants, singlet oxygen, and hypochlorous acid. In addition, recent information concerning the mechanisms of formation, individual measurement, and repair-rate assessment of bipyrimidine photoproducts in isolated cells and human skin upon exposure to UVB radiation, UVA photons, or solar simulated light is critically reviewed.

引用

页数：18

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