Differential expression of KDR/VEGFR-2 and CD34 during mesoderm development of the early human embryo

被引：55

作者：

Cortés, F ^{[1
]}

Debacker, C ^{[1
]}

Péault, B ^{[1
]}

Labastie, MC ^{[1
]}

机构：

[1] Inst Embryol Cellulaire & Mol, CNRS UPR 9064, F-94736 Nogent Sur Marne, France

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 83卷 / 1-2期

关键词：

VEGFR-2; KDR; CD34; mesoderm; hematopoietic stem cell; endothelium; human embryo;

D O I：

10.1016/S0925-4773(99)00030-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent findings on vertebrate embryos have provided compelling evidence for the existence of hemangioblasts, i.e. common precursors for endothelial and hematopoietic cells, characterized by expression of the VEGFR2/Flk1 receptor. We describe here a population of KDR+ CD34(-) mesoderm cells that emerges in early-semitic human embryos, by the beginning of the 4th week of gestation. In the developing blood vessels, KDR-expressing CD34(-) cells gradually coexpress increasing levels of CD34 antigen. Remarkably, as development proceeds, a KDR+ CD34(-) contingent persists in the paraaortic splanchnopleura until just prior to the emergence of aorta-associated hematopoietic cell clusters. These observations suggest that KDR+ CD34(-) mesodermal cells might represent the putative hemangioblastic precursor of human hematopoietic and endothelial lineages. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 164

页数：4

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