Trough Concentrations of Vancomycin Adult Therapeutic Targets Are Not Appropriate for Children

被引：35

作者：

Gordon, Claire L. ^{[1
]}

Thompson, Chantelle ^{[2
]}

Carapetis, Jonathan R. ^{[1
,3
,4
,5
]}

Turnidge, John ^{[6
,7
]}

Kilburn, Charles ^{[4
,5
]}

Currie, Bart J. ^{[1
]}

机构：

[1] Royal Darwin Hosp, Dept Infect Dis, Tiwi, NT 0810, Australia

[2] Royal Darwin Hosp, Dept Pharm, Tiwi, NT 0810, Australia

[3] Royal Darwin Hosp, Dept Paediat, Darwin, NT, Australia

[4] Telethon Inst Child Hlth Res, Perth, WA, Australia

[5] Univ Western Australia, Perth, WA 6009, Australia

[6] Womens & Childrens Hosp, SA Pathol, Adelaide, SA, Australia

[7] Univ Adelaide, Adelaide, SA, Australia

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 12期

关键词：

vancomycin; Staphylococcus aureus; therapeutic drug monitoring; RESISTANT STAPHYLOCOCCUS-AUREUS; BACTEREMIA; OUTCOMES; INFECTIONS;

D O I：

10.1097/INF.0b013e31826a3eaf

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

引用

页码：1269 / 1271

页数：3

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