The neuroanatomical and neurochemical basis of conditioned fear

被引：822

作者：

Fendt, M

Fanselow, MS

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1999年 / 23卷 / 05期

基金：

美国国家科学基金会;

关键词：

conditioned fear; fear-potentiated startle; conditioned stimulus; unconditioned stimulus; periaqueductal gray; amygdala; freezing;

D O I：

10.1016/S0149-7634(99)00016-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

After a few pairings of a threatening stimulus with a formerly neutral cue, animals and humans will experience a state of conditioned fear when only the cue is present. Conditioned fear provides a critical survival-related function in the face of threat by activating a range of protective behaviors. The present review summarizes and compares the results of different laboratories investigating the neuroanatomical and neurochemical basis of conditioned fear, focusing primarily on the behavioral models of freezing and fear-potentiated startle in rats. On the basis of these studies, we describe the pathways mediating and modulating fear. We identify several key unanswered questions and discuss possible implications for the understanding of human anxiety disorders. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：743 / 760

页数：18

共 231 条

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