Astrocytes function in matching blood flow to metabolic activity

被引：101

作者：

Harder, DR

Zhang, CY

Gebremedhin, D

机构：

[1] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Cardiovasc Res Ctr, Milwaukee, WI 53226 USA

[3] Zablocki Vet Affairs Med Ctr, Milwaukee, WI 53226 USA

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/physiologyonline.2002.17.1.27

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The brain possesses an intrinsic regulatory mechanism to maintain an adequate Supply Of O-2 and nutrition despite local increases in neuronal activity. Brain astrocytes function as an intermediary cell type by responding to glutamate released from activated neurons, and they couple cerebral blood flow by producing cytochrome P-450-derived epoxyeicosatrienoic acids that induce vasodilation and increase capillary density.

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页码：27 / 31

页数：5

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