4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-α-induced blood-brain barrier opening

被引：18

作者：

Megyeri, P

Németh, L

Pabst, KM

Pabst, MJ

Deli, MA

Abrahám, CS

机构：

[1] Albert Szent Gyorgyi Med Univ, Dept Pediat, H-6701 Szeged, Hungary

[2] Univ Tennessee, Dent Res Ctr, Memphis, TN 38163 USA

[3] Univ Tennessee, Dept Biochem, Memphis, TN 38163 USA

[4] Biol Res Ctr, Inst Biophys, Mol Neurobiol Lab, H-6701 Szeged, Hungary

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 374卷 / 02期

基金：

匈牙利科学研究基金会;

关键词：

AEBSF [4-(2-aminoethyl)benzenesulfonyl] fluoride; blood-brain barrier; brain edema; serine protease inhibitor; TNF-alpha (tumor necrosis factor-alpha);

D O I：

10.1016/S0014-2999(99)00224-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF) was investigated on the prevention of tumor-necrosis-factor-alpha (TNF-alpha)-induced blood-brain barrier opening. TNF-alpha (10,000 IU) was injected intracarotidly to newborn pigs pretreated with 0, 2.4, 4.8, 9.6 and 19.2 mg/kg AEBSF (n = 6 in each group). AEBSF dose-dependently inhibited the TNF-a-induced increase in the blood-brain barrier permeability for sodium fluorescein (MW = 376) in all of the five brain regions examined, while only 19.2 mg/kg AEBSF could significantly (P < 0.05) decrease the change in Evan's blue-albumin (MW = 67,000) transport in two regions. In conclusion, AEBSF attenuates vasogenic brain edema formation. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：207 / 211

页数：5

共 19 条

[1]

Abraham CS, 1996, NEUROSCI LETT, V208, P85

[2]

BANKS WA, 1994, J NEUROCHEM, V62, P2404

[3]

BEUTLER B, 1993, CRIT CARE MED, V21, pS423

[4] Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF [J].