Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes

被引：56

作者：

Genc, K ^{[1
]}

Genc, S

Baskin, H

Semin, I

机构：

[1] Dokuz Eylul Univ, Sch Med, Learning Resources Ctr, Res Lab, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Sch Med, Dept Microbiol, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Sch Med, Dept Physiol, TR-35340 Izmir, Turkey

来源：

PHYSIOLOGICAL RESEARCH | 2006年 / 55卷 / 01期

关键词：

erythropoietin; oligodendrocyte; cytotoxicity; lipopolysaccharide; interferon-gamma; nitric oxide;

D O I：

10.33549/physiolres.930749

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In the present study, we investigated whether erythropoietin (Epo) has a protective effect against cytotoxicity induced by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) in primary rat oligodendrocyte cultures. The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed. Erythropoietin exerted a significant protective effect against IFN-gamma and LPS-induced oligodendrocyte injury as determined by lactate dehydrogenase assay. Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. These results suggest that erythropoietin has protective effects against inflammatory oligodendrocyte injury in vitro and may play a protective role in neurological disorders characterized by oligodendrocyte death, Such as multiple sclerosis.

引用

页码：33 / 38

页数：6

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