Dose of propofol for laryngeal mask airway insertion in children: Effect of premedication with midazolam

被引:36
作者
Martlew, RA
Meakin, G
Wadsworth, R
Sharples, A
Baker, RD
机构
[1] UNIV MANCHESTER,ROYAL MANCHESTER CHILDRENS HOSP,DEPT ANAESTHESIA,MANCHESTER M27 4HA,LANCS,ENGLAND
[2] UNIV SALFORD,DEPT MATH,SALFORD M5 4WT,LANCS,ENGLAND
关键词
anaesthesia; paediatric; anaesthetics iv; propofol; premedication; midazolam; equipment; masks anaesthesia; children;
D O I
10.1093/bja/76.2.308
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We determined the dose-response curves and effective doses of propofol for insertion of the laryngeal mask airway (LMA) in 50 unpremedicated children and in 60 children premedicated with midazolam, aged 3-12 yr. One of several doses of propofol was administered i.v. over 15 s to groups of 10 children, and conditions for LMA insertion were assessed at 60 s. The dose-response curves were parallel (P = 0.94), but the curve for premedicated children was shifted significantly to the left of that for unpremedicated children and propofol requirements were reduced by one-third (P < 0.0001). The doses required for satisfactory LMA insertion in 50% and 90% of unpremedicated patients (ED(50), ED(90)) (95% confidence interval) were 3.8 (3.4-4.2) mg kg(-1) and 5.4 (4.7-6.8) mg kg(-1), respectively; those for premedicated patients were 2.6 (2.2-2.8) mg kg(-1) and 3.6 (3.2-4.3) mg kg(-1), respectively.
引用
收藏
页码:308 / 309
页数:2
相关论文
共 10 条
[1]  
AITKIN M, 1989, STATISTICAL MODELLIN, P192
[2]   DOSE OF PROPOFOL REQUIRED TO INSERT THE LARYNGEAL MASK AIRWAY IN CHILDREN [J].
ALLSOP, E ;
INNES, P ;
JACKSON, M ;
CUNLIFFE, M .
PAEDIATRIC ANAESTHESIA, 1995, 5 (01) :47-51
[3]  
[Anonymous], PAEDIAT ANAESTH
[4]   PROPOFOL INDUCTION FOR LARYNGEAL MASK AIRWAY INSERTION - DOSE REQUIREMENT AND CARDIORESPIRATORY EFFECTS [J].
BLAKE, DW ;
DAWSON, P ;
DONNAN, G ;
BJORKSTEN, A .
ANAESTHESIA AND INTENSIVE CARE, 1992, 20 (04) :479-483
[5]  
BRAIN AIJ, 1991, INTAVENT LARYNGEAL M, P7
[6]   COMPARISON OF PROPOFOL AND THIOPENTONE FOR LARYNGEAL MASK INSERTION [J].
BROWN, GW ;
PATEL, N ;
ELLIS, FR .
ANAESTHESIA, 1991, 46 (09) :771-772
[7]   PHARMACOKINETIC MODEL DRIVEN INFUSION OF PROPOFOL IN CHILDREN [J].
MARSH, B ;
WHITE, M ;
MORTON, N ;
KENNY, GNC .
BRITISH JOURNAL OF ANAESTHESIA, 1991, 67 (01) :41-48
[8]  
MCCLUSKEY A, 1994, ANAESTHESIA, V49, P782
[9]   PHARMACOKINETICS OF PROPOFOL IN YOUNG-CHILDREN AFTER A SINGLE DOSE [J].
SAINTMAURICE, C ;
COCKSHOTT, ID ;
DOUGLAS, EJ ;
RICHARD, MO ;
HARMEY, JL .
BRITISH JOURNAL OF ANAESTHESIA, 1989, 63 (06) :667-670
[10]   PROPOFOL AND MIDAZOLAM ACT SYNERGISTICALLY IN COMBINATION [J].
SHORT, TG ;
CHUI, PT .
BRITISH JOURNAL OF ANAESTHESIA, 1991, 67 (05) :539-545