Evolutionary rate differences in trypanosomes

被引：45

作者：

Stevens, Jamie ^{[1
]}

Rambaut, Andrew ^{[2
]}

机构：

[1] Univ Exeter, Sch Biol Sci, Exeter EX4 4PS, Devon, England

[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

INFECTION GENETICS AND EVOLUTION | 2001年 / 1卷 / 02期

基金：

英国惠康基金;

关键词：

Trypanosoma brucei; Trypanosoma cruzi; Evolution; Phylogenetics; Maximum likelihood; Small subunit ribosomal RNA; Biogeography;

D O I：

10.1016/S1567-1348(01)00018-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Ribosomal RNA-based studies of trypanosome phylogenies have highlighted considerable differences in genetic diversity within clades in the genus Trypanosoma and several-fold substitution rate differences between clades have been identified. While early 18S rRNA-based studies were hampered by highly variable substitution rates and long-branch attraction, it is apparent that genuine differences in evolution rates within localized clades do exist and questions remain regarding what rate or rates such clades are evolving at and why is the application of a single clock to trypanosome evolution so inappropriate? In this study, we explore rate heterogeneity in the commonly used 18S rRNA gene across genus Trypanosoma, using a maximum likelihood (ML) approach to explore local rate variations in clades of biological interest. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：143 / 150

页数：8

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