Nicotine enhances both foreground and background contextual fear conditioning

被引:60
作者
Davis, JA [1 ]
Porter, J [1 ]
Gould, TJ [1 ]
机构
[1] Temple Univ, Dept Psychol, Program Neurosci, Philadelphia, PA 19122 USA
关键词
learning; hippocampus; nicotine; mice; acetylcholine; context;
D O I
10.1016/j.neulet.2005.10.026
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:202 / 205
页数:4
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