Postsynaptic induction of BDNF-mediated long-term potentiation

被引：374

作者：

Kovalchuk, Y ^{[1
]}

Hanse, E ^{[1
]}

Kafitz, KW ^{[1
]}

Konnerth, A ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol, D-80336 Munich, Germany

来源：

SCIENCE | 2002年 / 295卷 / 5560期

关键词：

D O I：

10.1126/science.1067766

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca2+ transients in dendrites and spines, but not at presynaptic sites. Pairing a weak burst of synaptic stimulation with a brief dendritic BDNF application caused an immediate and robust induction of LTP. LTP induction required activation of postsynaptic Ca2+ channels and N-methyl-D-aspartate receptors and was prevented by the blockage of postsynaptic Call transients. Thus, our results suggest that BDNF-mediated LTP is induced postsynaptically. Our finding that dendritic spines are the exclusive synaptic sites for rapid BDNF-evoked Ca2+ signaling supports this conclusion.

引用

页码：1729 / 1734

页数：6

共 37 条

[1] ENTORHINAL ACTIVATION OF DENTATE GRANULE CELLS [J].