Therapeutic inhibition of Hedgehog-GLI signaling in cancer: Epithelial, stromal, or stem cell targets?

被引：54

作者：

Altaba, Ariel Ruiz I. ^{[1
]}

机构：

[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

来源：

CANCER CELL | 2008年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2008.09.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk prolifertion that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLl signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.

引用

页码：281 / 283

页数：3

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