Grignard reactions to chiral oxazolidine aldehydes

被引：134

作者：

Williams, L ^{[1
]}

Zhang, ZD ^{[1
]}

Shao, F ^{[1
]}

Carroll, PJ ^{[1
]}

Joullie, MM ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON | 1996年 / 52卷 / 36期

关键词：

D O I：

10.1016/0040-4020(96)00672-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modest to high levels of asymmetric induction are observed with Grignard additions to Garner type aldehydes. The resultant secondary alcohols are important precursors of chiral building blocks for asymmetric synthesis and we have demonstrated that they can be readily converted into their respective gamma-hydroxy-beta-amino alcohols and P-hydroxyamino acids. Additionally, aryloxy ethers, important components of many natural products, can be obtained from these precursors. Copyright (C) 1996 Elsevier Science Ltd

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页码：11673 / 11694

页数：22

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