Vaccines for pandemic influenza

被引:101
作者
Luke, CJ [1 ]
Subbarao, K [1 ]
机构
[1] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.3201/eid1201.051147
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent outbreaks of highly pathogenic avian influenza in Asia and associated human infections have led to a heightened level of awareness and preparation for a possible influenza pandemic. Vaccination is the best option by which spread of a pandemic virus could be prevented and severity of disease reduced. Production of live attenuated and inactivated vaccine seed viruses against avian influenza viruses, which have the potential to cause pandemics, and their testing in preclinical studies and clinical trials will establish the principles and ensure manufacturing experience that will be critical in the event of the emergence of such a virus into the human population. Studies of such vaccines will also add to our understanding of the biology of avian influenza viruses and their behavior in mammalian hosts.
引用
收藏
页码:66 / 72
页数:7
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