Ceramide-1-phosphate: The "missing" link in eicosanold biosynthesis and onflammation

被引：66

作者：

Lamour, NF

Chalfant, CE

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem, Richmond, VA 23298 USA

[2] Massey Canc Ctr, Richmond, VA 23298 USA

[3] Hunter Holmes McGuire Vet Adm Med Ctr, Res & Dev, Richmond, VA 23249 USA

来源：

MOLECULAR INTERVENTIONS | 2005年 / 5卷 / 06期

关键词：

D O I：

10.1124/mi.5.6.8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been over a decade since ceramide kinase (CERK) and its product, ceramide-1-phosphate (C1P), were first reported. Since its cloning, in 2002, CERK has been the subject of an explosion of publications concerning various signal transduction pathways. The roles of this previously overlooked enzyme, as well as those of its product C1P, continue to expand, and their regulatory functions in the production of eicosanoid inflammatory mediators are proving essential to fundamental signal transduction pathways. In particular, C1P is required for the activation and translocation of cPLA(2)alpha, the initial rate-limiting step of eicosanoid synthesis. The potential for inhibitors of CERK to offer a new generation of anti-inflammatory and anti-cancer therapeutics is especially deserving of further study.

引用

页码：358 / 367

页数：10

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