Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle

被引：18

作者：

Woodard, GE ^{[1
]}

Rosado, JA ^{[1
]}

Brown, J ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol, Cambridge CB2 3EG, England

来源：

PEPTIDES | 2002年 / 23卷 / 01期

关键词：

CNP; DNP; vascular smooth muscle;

D O I：

10.1016/S0196-9781(01)00575-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendroaspis natriuretic peptide (DNP) is a recently isolated 38 amino acid peptide that shares structural and functional properties with the other members of the natriuretic peptide family. The present study demonstrates the presence of DNP-like immunoreactivity in sections of rat aorta, carotid artery and renal vasculature and tubules. DNP-like immunoreactivity was detected in culture aortic vascular smooth muscle cells and medium and is regulated by endothelin-1, angiotensin II and sodium nitroprusside but not by transforming growth factor-beta. Our observations indicate that DNP elicits a marked inhibitory effect on DNA synthesis in culture rat aortic vascular smooth muscle cells. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：23 / 29

页数：7

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