Fluorochrome-Functionalized Magnetic Nanoparticles for High-Sensitivity Monitoring of the Polymerase Chain Reaction by Magnetic Resonance

被引：28

作者：

Alcantara, David ^{[1
,2
]}

Guo, Yanyan ^{[1
]}

Yuan, Hushan ^{[1
]}

Goergen, Craig J. ^{[3
]}

Chen, Howard H. ^{[3
]}

Cho, Hoonsung ^{[1
]}

Sosnovik, David E. ^{[1
,3
]}

Josephson, Lee ^{[1
,3
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Translat Nucl Med & Mol Imaging, Charlestown, MA 02129 USA

[2] Univ Zaragoza, Inst Nanociencia Aragon, Zaragoza 50018, Spain

[3] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 28期

关键词：

fluorescence; imaging agents; magnetic nanoparticles; magnetic resonance imaging; polymerase chain reaction; THIAZOLE ORANGE; MOLECULAR-INTERACTIONS; DNA; NMR; PURIFICATION; FERUMOXYTOL; NANOSENSORS; EXTRACTION; KINETICS; BINDING;

D O I：

10.1002/anie.201201661

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Easy to find: Magnetic nanoparticles bearing fluorochromes (red) that intercalate with DNA (green) form microaggregates with DNA generated by the polymerase chain reation (PCR). These aggregates can be detected at low cycle numbers by magnetic resonance (MR). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6904 / 6907

页数：4

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