Polydnavirus-mediated suppression of insect immunity

被引：106

作者：

Shelby, KS ^{[1
]}

Webb, BA ^{[1
]}

机构：

[1] Univ Kentucky, Dept Entomol, Lexington, KY 40546 USA

来源：

JOURNAL OF INSECT PHYSIOLOGY | 1999年 / 45卷 / 05期

关键词：

Campoletis sonorensis polydnavirus; Heliothis virescens; antibacterial response; lysozyme; catecholamines; phenoloxidase; dopachrome tautomerase; immunodeficiency;

D O I：

10.1016/S0022-1910(98)00144-9

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Polydnaviruses are symbiotic proviruses of some ichneumonid and braconid wasps that modify the physiology, growth and development of host lepidopteran larvae. Polydnavirus infection targets neuroendocrine and immune systems, altering behavior, stunting growth, and immobilizing immune responses to wasp eggs and larvae. Polydnavirus-mediated disruption of cellular and humoral immunity renders parasitized lepidopteran larvae suitable for development of wasp larvae as well as more susceptible to opportunistic infections. Evidence from the Canpoletis sonorensis polydnavirus system indicates that the unique genomic organization of polydnaviruses may have evolved to amplify the synthesis of immunosuppressive viral proteins. Immunosuppressive viruses have been essential to elucidating vertebrate immunity. Polydnaviruses have similar potential to clarify insect immune responses and may also provide novel insights into the role of insect immunity in shaping polpdnavirus genomes. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：507 / 514

页数：8

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