Polydnavirus-mediated suppression of insect immunity

被引:105
作者
Shelby, KS [1 ]
Webb, BA [1 ]
机构
[1] Univ Kentucky, Dept Entomol, Lexington, KY 40546 USA
关键词
Campoletis sonorensis polydnavirus; Heliothis virescens; antibacterial response; lysozyme; catecholamines; phenoloxidase; dopachrome tautomerase; immunodeficiency;
D O I
10.1016/S0022-1910(98)00144-9
中图分类号
Q96 [昆虫学];
学科分类号
摘要
Polydnaviruses are symbiotic proviruses of some ichneumonid and braconid wasps that modify the physiology, growth and development of host lepidopteran larvae. Polydnavirus infection targets neuroendocrine and immune systems, altering behavior, stunting growth, and immobilizing immune responses to wasp eggs and larvae. Polydnavirus-mediated disruption of cellular and humoral immunity renders parasitized lepidopteran larvae suitable for development of wasp larvae as well as more susceptible to opportunistic infections. Evidence from the Canpoletis sonorensis polydnavirus system indicates that the unique genomic organization of polydnaviruses may have evolved to amplify the synthesis of immunosuppressive viral proteins. Immunosuppressive viruses have been essential to elucidating vertebrate immunity. Polydnaviruses have similar potential to clarify insect immune responses and may also provide novel insights into the role of insect immunity in shaping polpdnavirus genomes. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:507 / 514
页数:8
相关论文
共 57 条
[1]  
ALBRECHT U, 1996, J GEN VIROL, V75, P3353
[2]   IMMUNE-RESPONSES IN TRICHOPLUSIA-NI CHALLENGED WITH BACTERIA OR BACULOVIRUSES [J].
ANDERSONS, D ;
GUNNE, H ;
HELLERS, M ;
JOHANSSON, H ;
STEINER, H .
INSECT BIOCHEMISTRY, 1990, 20 (05) :537-543
[3]   A polydnavirus-encoded protein of an endoparasitoid wasp is an immune suppressor [J].
Asgari, S ;
Schmidt, O ;
Theopold, U .
JOURNAL OF GENERAL VIROLOGY, 1997, 78 :3061-3070
[4]   A protein with protective properties against the cellular defense reactions in insects [J].
Asgari, S ;
Theopold, U ;
Wellby, C ;
Schmidt, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3690-3695
[5]   SEGMENT-W OF CAMPOLETIS-SONORENSIS VIRUS - EXPRESSION, GENE-PRODUCTS, AND ORGANIZATION [J].
BLISSARD, GW ;
THEILMANN, DA ;
SUMMERS, MD .
VIROLOGY, 1989, 169 (01) :78-89
[6]  
Brooks Wayne M., 1993, P231
[7]   Drosophila cellular immunity against parasitoids [J].
Carton, Y ;
Nappi, AJ .
PARASITOLOGY TODAY, 1997, 13 (06) :218-227
[8]   A SUGGESTED ROLE FOR PHOSPHOLIPASE-C IN THE IMMUNE-RESPONSE OF GALLERIA-MELLONELLA [J].
CHIU, JKC ;
ASTON, WP ;
CHADWICK, JS .
JOURNAL OF INVERTEBRATE PATHOLOGY, 1991, 57 (01) :128-130
[9]   Isolation and characterization of a member of the cysteine-rich gene family from Campoletis sonorensis polydnavirus [J].
Cui, LW ;
Webb, BA .
JOURNAL OF GENERAL VIROLOGY, 1996, 77 :797-809
[10]  
Cui LW, 1997, ARCH INSECT BIOCHEM, V36, P251, DOI 10.1002/(SICI)1520-6327(1997)36:4<251::AID-ARCH2>3.0.CO