Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

被引：15

作者：

Bardak-Ozcem, Selin ^{[1
]}

Turhan, Tuncer ^{[2
]}

Sipahi, Oguz Resat ^{[1
]}

Arda, Bilgin ^{[1
]}

Pullukcu, Husnu ^{[1
]}

Yamazhan, Tansu ^{[1
]}

Isikgoz-Tasbakan, Meltem ^{[1
]}

Sipahi, Hilal ^{[3
]}

Ulusoy, Sercan ^{[1
]}

机构：

[1] Ege Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Izmir, Turkey

[2] Ege Univ, Fac Med, Dept Neurosurg, Izmir, Turkey

[3] Bornova Publ Hlth Ctr, Izmir, Turkey

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 03期

关键词：

D O I：

10.1128/AAC.01996-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P<0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.

引用

页码：1556 / 1558

页数：3

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