Sleep as a fundamental property of neuronal assemblies

被引：386

作者：

Krueger, James M. ^{[1
,2
,3
,4
,5
]}

Rector, David M. ^{[2
,3
,4
,5
]}

Roy, Sandip ^{[6
,7
]}

Van Dongen, Hans P. A. ^{[2
,3
,4
,5
]}

Belenky, Gregory ^{[2
,3
,4
,5
]}

Panksepp, Jaak ^{[2
,3
,4
,5
]}

机构：

[1] Washington State Univ, Coll Vet Med, Dept VCAPP, Pullman, WA 99164 USA

[2] Washington State Univ, Sleep & Performance Res Ctr, Pullman, WA 99164 USA

[3] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA 99164 USA

[4] Washington State Univ, Program Neurosci, Pullman, WA 99164 USA

[5] Washington State Univ, Program Neurosci, Spokane, WA 99164 USA

[6] Washington State Univ, Programs Elect Engn, Pullman, WA 99164 USA

[7] Washington State Univ, Programs Elect Engn, Spokane, WA 99164 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 12期

基金：

美国国家卫生研究院; 美国国家航空航天局; 美国国家科学基金会;

关键词：

D O I：

10.1038/nrn2521

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep is vital to cognitive performance, productivity, health and well-being. Earlier theories of sleep presumed that it occurred at the level of the whole organism and that it was governed by central control mechanisms. However, evidence now indicates that sleep might be regulated at a more local level in the brain: it seems to be a fundamental property of neuronal networks and is dependent on prior activity in each network. Such local-network sleep might be initiated by metabolically driven changes in the production of sleep-regulatory substances. We discuss a mathematical model which illustrates that the sleep-like states of individual cortical columns can be synchronized through humoral and electrical connections, and that whole-organism sleep occurs as an emergent property of local-network interactions.

引用

页码：910 / 919

页数：10

共 101 条

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