Schizophrenia - Incriminating genomic evidence

被引：26

作者：

Lupski, James R. ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Houston, TX 77030 USA

来源：

NATURE | 2008年 / 455卷 / 7210期

关键词：

D O I：

10.1038/455178a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genetic factors that contribute to schizophrenia can vary, making it difficult to pinpoint which DNA changes are the main culprits. Large genome-wide studies provide the most reliable clues yet.

引用

页码：178 / 179

页数：2

共 13 条

[1]

Burmeister M, 2008, NAT REV GENET, V9, P527, DOI 10.1038/nrg2381

[2] Recurrent 16p11.2 microdeletions in autism [J].

Kumar, Ravinesh A. ;

KaraMohamed, Samer ;

Sudi, Jyotsna ;

Conrad, Donald F. ;

Brune, Camille ;

Badner, Judith A. ;

Gilliam, T. Conrad ;

Nowak, Norma J. ;

Cook, Edwin H., Jr. ;

Dobyns, William B. ;

Christian, Susan L. .

HUMAN MOLECULAR GENETICS, 2008, 17 (04) :628-638

[3] Genomic rearrangements and sporadic disease [J].

Lupski, James R. .

NATURE GENETICS, 2007, 39 (Suppl 7) :S43-S47

[4] DNA DUPLICATION ASSOCIATED WITH CHARCOT-MARIE-TOOTH DISEASE TYPE-1A [J].

LUPSKI, JR ;

DEOCALUNA, RM ;

SLAUGENHAUPT, S ;

PENTAO, L ;

GUZZETTA, V ;

TRASK, BJ ;

SAUCEDOCARDENAS, O ;

BARKER, DF ;

KILLIAN, JM ;

GARCIA, CA ;

CHAKRAVARTI, A ;

PATEL, PI .

CELL, 1991, 66 (02) :219-232

[5] Genomic disorders: structural features of the genome can lead to DNA rearrangements and human disease traits [J].

Lupski, JR .

TRENDS IN GENETICS, 1998, 14 (10) :417-422

[6] Identifying autism loci and genes by tracing recent shared ancestry [J].

Morrow, Eric M. ;

Yoo, Seung-Yun ;

Flavell, Steven W. ;

Kim, Tae-Kyung ;

Lin, Yingxi ;

Hill, Robert Sean ;

Mukaddes, Nahit M. ;

Balkhy, Soher ;

Gascon, Generoso ;

Hashmi, Asif ;

Al-Saad, Samira ;

Ware, Janice ;

Joseph, Robert M. ;

Greenblatt, Rachel ;

Gleason, Danielle ;

Ertelt, Julia A. ;

Apse, Kira A. ;

Bodell, Adria ;

Partlow, Jennifer N. ;

Barry, Brenda ;

Yao, Hui ;

Markianos, Kyriacos ;

Ferland, Russell J. ;

Greenberg, Michael E. ;

Walsh, Christopher A. .

SCIENCE, 2008, 321 (5886) :218-223

[7] Strong association of de novo copy number mutations with autism [J].

Sebat, Jonathan ;

Lakshmi, B. ;

Malhotra, Dheeraj ;

Troge, Jennifer ;

Lese-Martin, Christa ;

Walsh, Tom ;

Yamrom, Boris ;

Yoon, Seungtai ;

Krasnitz, Alex ;

Kendall, Jude ;

Leotta, Anthony ;

Pai, Deepa ;

Zhang, Ray ;

Lee, Yoon-Ha ;

Hicks, James ;

Spence, Sarah J. ;

Lee, Annette T. ;

Puura, Kaija ;

Lehtimaeki, Terho ;

Ledbetter, David ;

Gregersen, Peter K. ;

Bregman, Joel ;

Sutcliffe, James S. ;

Jobanputra, Vaidehi ;

Chung, Wendy ;

Warburton, Dorothy ;

King, Mary-Claire ;

Skuse, David ;

Geschwind, Daniel H. ;

Gilliam, T. Conrad ;

Ye, Kenny ;

Wigler, Michael .

SCIENCE, 2007, 316 (5823) :445-449

[8] A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures [J].

Sharp, Andrew J. ;

Mefford, Heather C. ;

Li, Kelly ;

Baker, Carl ;

Skinner, Cindy ;

Stevenson, Roger E. ;

Schroer, Richard J. ;

Novara, Francesca ;

De Gregori, Manuela ;

Ciccone, Roberto ;

Broomer, Adam ;

Casuga, Iris ;

Wang, Yu ;

Xiao, Chunlin ;

Barbacioru, Catalin ;

Gimelli, Giorgio ;

Bernardina, Bernardo Dalla ;

Torniero, Claudia ;

Giorda, Roberto ;

Regan, Regina ;

Murday, Victoria ;

Mansour, Sahar ;

Fichera, Marco ;

Castiglia, Lucia ;

Failla, Pinella ;

Ventura, Mario ;

Jiang, Zhaoshi ;

Cooper, Gregory M. ;

Knight, Samantha J. L. ;

Romano, Corrado ;

Zuffardi, Orsetta ;

Chen, Caifu ;

Schwartz, Charles E. ;

Eichler, Evan E. .

NATURE GENETICS, 2008, 40 (03) :322-328

[9] Large recurrent microdeletions associated with schizophrenia [J].

Stefansson, Hreinn ;

Rujescu, Dan ;

Cichon, Sven ;

Pietilainen, Olli P. H. ;

Ingason, Andres ;

Steinberg, Stacy ;

Fossdal, Ragnheidur ;

Sigurdsson, Engilbert ;

Sigmundsson, Thordur ;

Buizer-Voskamp, Jacobine E. ;

Hansen, Thomas ;

Jakobsen, Klaus D. ;

Muglia, Pierandrea ;

Francks, Clyde ;

Matthews, Paul M. ;

Gylfason, Arnaldur ;

Halldorsson, Bjarni V. ;

Gudbjartsson, Daniel ;

Thorgeirsson, Thorgeir E. ;

Sigurdsson, Asgeir ;

Jonasdottir, Adalbjorg ;

Jonasdottir, Aslaug ;

Bjornsson, Asgeir ;

Mattiasdottir, Sigurborg ;

Blondal, Thorarinn ;

Haraldsson, Magnus ;

Magnusdottir, Brynja B. ;

Giegling, Ina ;

Moeller, Hans-Juergen ;

Hartmann, Annette ;

Shianna, Kevin V. ;

Ge, Dongliang ;

Need, Anna C. ;

Crombie, Caroline ;

Fraser, Gillian ;

Walker, Nicholas ;

Lonnqvist, Jouko ;

Suvisaari, Jaana ;

Tuulio-Henriksson, Annamarie ;

Paunio, Tiina ;

Toulopoulou, Timi ;

Bramon, Elvira ;

Di Forti, Marta ;

Murray, Robin ;

Ruggeri, Mirella ;

Vassos, Evangelos ;

Tosato, Sarah ;

Walshe, Muriel ;

Li, Tao ;

Vasilescu, Catalina .

NATURE, 2008, 455 (7210) :232-U61

[10] Rare chromosomal deletions and duplications increase risk of schizophrenia [J].

Stone, Jennifer L. ;

O'Donovan, Michael C. ;

Gurling, Hugh ;

Kirov, George K. ;

Blackwood, Douglas H. R. ;

Corvin, Aiden ;

Craddock, Nick J. ;

Gill, Michael ;

Hultman, Christina M. ;

Lichtenstein, Paul ;

McQuillin, Andrew ;

Pato, Carlos N. ;

Ruderfer, Douglas M. ;

Owen, Michael J. ;

St Clair, David ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Purcell, Shaun M. ;

Scolnick, E. M. ;

Holmans, P. A. ;

Georgieva, L. ;

Nikolov, I. ;

Norton, N. ;

Williams, H. ;

Williams, N. M. ;

Toncheva, D. ;

Milanova, V. ;

Thelander, E. F. ;

Morris, D. W. ;

O'Dushlaine, C. T. ;

Kenny, E. ;

Waddington, J. L. ;

Choudhury, K. ;

Datta, S. ;

Pimm, J. ;

Thirumalai, S. ;

Puri, V. ;

Krasucki, R. ;

Lawrence, J. ;

Quested, D. ;

Bass, N. ;

Curtis, D. ;

Crombie, C. ;

Fraser, G. ;

Kwan, S. L. ;

Muir, W. J. ;

McGhee, K. A. ;

Pickard, B. ;

Malloy, P. ;

Maclean, A. W. .

NATURE, 2008, 455 (7210) :237-241

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