Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen

被引：50

作者：

Inaba, Hiroaki ^{[2
]}

Hokamura, Kazuya ^{[3
]}

Nakano, Kazuhiko ^{[4
]}

Nomura, Ryota ^{[4
]}

Katayama, Kazufumi ^{[1
]}

Nakajima, Atsushi ^{[5
]}

Yoshioka, Hideo ^{[6
]}

Taniguchi, Kazuhiro ^{[7
]}

Kamisaki, Yoshinori ^{[1
]}

Ooshima, Takashi ^{[4
]}

Umemura, Kazuo ^{[3
]}

Murad, Ferid ^{[8
]}

Wada, Koichiro ^{[1
]}

Amano, Atsuo ^{[2
]}

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Pharmacol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Dent, Dept Oral Frontier Biol, Suita, Osaka 5650871, Japan

[3] Hamamatsu Univ Sch Med, Dept Pharmacol, Hamamatsu, Shizuoka 4313192, Japan

[4] Osaka Univ, Grad Sch Dent, Dept Pediat Dent, Suita, Osaka 5650871, Japan

[5] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan

[6] Osaka Rosai Hosp, Dept Dent & Oral Surg, Sakai, Osaka 5910825, Japan

[7] Osaka Rosai Hosp, Dept Cardiovasc Surg, Sakai, Osaka 5910825, Japan

[8] Univ Texas Houston, Hlth Sci Ctr, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 01期

基金：

日本学术振兴会;

关键词：

Smooth muscle cell; Proliferation; S100; Human; Porphyromonas gingivalis; PORPHYROMONAS-GINGIVALIS; BUERGERS-DISEASE; BACTERIA; PLAQUE;

D O I：

10.1016/j.febslet.2008.11.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of a periodontal pathogen, Porphyromonas gingivalis, on human aortic smooth muscle cell (hAOSMC) proliferation as mechanisms of atherosclerosis. Cultured hAOSMCs exposed to the supernatant of plasma incubated with P. gingivalis showed a marked transformation from a contractile to proliferative phenotype, resulting in enhancement of cell growth. DNA micro-array analysis revealed a P. gingivalis-dependent upregulation of S100A9 in hAOSMCs. Small interference-RNA for S100A9 dramatically attenuated the effect of P. gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：128 / 134

页数：7

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