BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal

被引：113

作者：

Pu, L ^{[1
]}

Liu, QS ^{[1
]}

Poo, MM ^{[1
]}

机构：

[1] Univ Calif Berkeley, Div Neurobiol, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn1687

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neural mechanism underlying the relapse to drug use after drug withdrawal is largely unknown. We found that after withdrawal from repeated cocaine exposure, excitatory synapses onto dopamine neurons in the ventral tegmental area (VTA) of the rat midbrain became highly susceptible to potentiation by weak presynaptic stimuli, an effect requiring endogenous brain-derived neurotrophic factor-tyrosine kinase B (BDNF-TrkB) signaling. The elevated BDNF expression in the VTA after cocaine withdrawal may prime these synapses for potentiation by cue-associated activity, triggering drug craving and relapse.

引用

页码：605 / 607

页数：3

共 15 条

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