Anabolic Resistance of Muscle Protein Synthesis with Aging

被引：282

作者：

Burd, Nicholas A. ^{[1
]}

Gorissen, Stefan H. ^{[1
]}

van Loon, Luc J. C. ^{[1
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Human Movement Sci, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2013年 / 41卷 / 03期

关键词：

sarcopenia; dietary protein; exercise; amino acids; mTORC1; ESSENTIAL AMINO-ACIDS; INSULIN-RESISTANCE; DOSE-RESPONSE; WHOLE-BODY; YOUNG; EXERCISE; ABSORPTION; INGESTION; LEUCINE; AGE;

D O I：

10.1097/JES.0b013e318292f3d5

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed "anabolic resistance." Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging.

引用

页码：169 / 173

页数：5

共 35 条

[1]

Boirie Y, 1997, AM J CLIN NUTR, V65, P489

[2] The curious case of anabolic resistance: old wives' tales or new fables? [J].

Burd, Nicholas A. ;

Wall, Benjamin T. ;

van Loon, Luc J. C. .

JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (07) :1233-1235

[3] Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men [J].

Burd, Nicholas A. ;

West, Daniel W. D. ;

Moore, Daniel R. ;

Atherton, Philip J. ;

Staples, Aaron W. ;

Prior, Todd ;

Tang, Jason E. ;

Rennie, Michael J. ;

Baker, Steven K. ;

Phillips, Stuart M. .

JOURNAL OF NUTRITION, 2011, 141 (04) :568-573

[4] Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men [J].

Churchward-Venne, Tyler A. ;

Burd, Nicholas A. ;

Mitchell, Cameron J. ;

West, Daniel W. D. ;

Philp, Andrew ;

Marcotte, George R. ;

Baker, Steven K. ;

Baar, Keith ;

Phillips, Stuart M. .

JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (11) :2751-2765

[5] Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle [J].

Cuthbertson, D ;

Smith, K ;

Babraj, J ;

Leese, G ;

Waddell, T ;

Atherton, P ;

Wackerhage, H ;

Taylor, PM ;

Rennie, MJ .

FASEB JOURNAL, 2004, 18 (15) :422-+

[6] Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise [J].

Dickinson, Jared M. ;

Drummond, Micah J. ;

Coben, Jennifer R. ;

Volpi, Elena ;

Rasmussen, Blake B. .

CLINICAL NUTRITION, 2013, 32 (02) :273-280

[7] Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults [J].

Drummond, Micah J. ;

Dickinson, Jared M. ;

Fry, Christopher S. ;

Walker, Dillon K. ;

Gundermann, David M. ;

Reidy, Paul T. ;

Timmerman, Kyle L. ;

Markofski, Melissa M. ;

Paddon-Jones, Douglas ;

Rasmussen, Blake B. ;

Volpi, Elena .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2012, 302 (09) :E1113-E1122

[8] Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis [J].

Fry, Christopher S. ;

Drummond, Micah J. ;

Glynn, Erin L. ;

Dickinson, Jared M. ;

Gundermann, David M. ;

Timmerman, Kyle L. ;

Walker, Dillon K. ;

Dhanani, Shaheen ;

Volpi, Elena ;

Rasmussen, Blake B. .

SKELETAL MUSCLE, 2011, 1

[9] Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism [J].

Fujita, S. ;

Glynn, E. L. ;

Timmerman, K. L. ;

Rasmussen, B. B. ;

Volpi, E. .

DIABETOLOGIA, 2009, 52 (09) :1889-1898

[10] Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling [J].

Fujita, Satoshi ;

Rasmussen, Blake B. ;

Cadenas, Jerson G. ;

Drummond, Micah J. ;

Glynn, Erin L. ;

Sattler, Fred R. ;

Volpi, Elena .

DIABETES, 2007, 56 (06) :1615-1622

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