Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile

被引：107

作者：

Al-Jamal, Khuloud T. ^{[2
]}

Nunes, Antonio ^{[2
]}

Methven, Laura ^{[2
]}

Ali-Boucetta, Hanene ^{[2
]}

Li, Shouping ^{[3
]}

Toma, Francesca M. ^{[1
]}

Herrero, M. Antonia ^{[1
]}

Al-Jamal, Wafa' T. ^{[2
]}

ten Eikelder, Huub M. M. ^{[4
]}

Foster, Julie ^{[5
]}

Mather, Stephen ^{[5
]}

Prato, Maurizio ^{[1
]}

Bianco, Alberto ^{[3
]}

Kostarelos, Kostas ^{[2
]}

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] UCL, UCL Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England

[3] CNRS, Lab Immunol & Chim Therapeut, Inst Biol Mol & Cellulaire, F-67000 Strasbourg, France

[4] Eindhoven Univ Technol, Biomodeling & Bioinformat Grp, NL-5600 MB Eindhoven, Netherlands

[5] St Bartholomews & London Hosp, Dept Nucl Med, London, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 26期

基金：

英国工程与自然科学研究理事会;

关键词：

biodistribution; functionalization; nanotubes; pharmacokinetics; toxicology; BIODISTRIBUTION; PHARMACOKINETICS; TRANSLOCATION; CIRCULATION; CHEMISTRY; FATE;

D O I：

10.1002/anie.201201991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6389 / 6393

页数：5

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