Nucleosome assembly: The CAF and the HAT

被引：45

作者：

Kaufman, PD ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

来源：

CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(96)80012-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent data argue strongly that a protein complex termed chromatin assembly factor-I (CAF-I) plays a major role in de novo nucleosome assembly during DNA replication. Human CAF-I deposits newly synthesized, acetylated histones onto replicated DNA in vitro and localizes to sites of DNA replication in S-phase cells. Specific lysines of the histones used for nucleosome assembly are acetylated; in the past year the first gene encoding a histone acetyltransferase was cloned. However, mechanistic links between histone acetylation and nucleosome assembly have not been established in vivo or in vitro.

引用

页码：369 / 373

页数：5

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