Estetrol: A unique steroid in human pregnancy

被引：65

作者：

Holinka, Christian F. ^{[1
]}

Diczfalusy, Egon ^{[2
]}

Bennink, Herjan J. T. Coelingh ^{[3
]}

机构：

[1] PharmConsult, New York, NY USA

[2] Karolinska Inst, Stockholm, Sweden

[3] Pantarhei Biosci, Zeist, Netherlands

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2008年 / 110卷 / 1-2期

关键词：

human pregnancy hormone; fetalsteroid; natural SERM;

D O I：

10.1016/j.jsbmb.2008.03.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Estetrol (E-4) is an estrogenic steroid molecule synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta. Its function is presently unknown. After its discovery in the mid-1960s, E4 research revealed rather unique properties of this steroid and spawned a large body of state-of-the art publications. Nevertheless, 20 years later experimental work was virtually abandoned. In recent years based on new data, E4 has experienced a vita nova, a revival of preclinical and clinical research activities with the goal to elucidate its physiological function and explore its potential for therapeutic use in humans. This review is intended to offer an historical account of the discovery of E4 and the preclinical studies conducted during the heyday of E4 research that ended in the mid-1980s. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：138 / 143

页数：6

共 59 条

[1]

ADLERCREUTZ H, 1970, Annals of Clinical Research, V2, P365

[2]

UNCONJUGATED ESTETROL IN PLASMA IN RESPONSE TO AN INTRAVENOUS LOAD OF DEHYDROEPIANDROSTERONE SULFATE (DHAS) IN UNCOMPLICATED AND COMPLICATED HUMAN PREGNANCY [J].