Selective T-Cell recognition of the N-terminal peptide of GroES in tuberculosis

被引：6

作者：

Chua-Intra, B

Wilkinson, RJ

Ivanyi, J

机构：

[1] Hammersmith Hosp, MRC Clin Sci Ctr, London W12 0NN, England

[2] Imperial Coll, Sch Med, Wellcome Ctr Clin Trop Med, Harrow HA1 3UJ, Middx, England

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 03期

关键词：

D O I：

10.1128/IAI.70.3.1645-1647.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peptides derived from the whole sequence of mycobacterial GroES heat shock proteins were tested for the ability to induce the proliferation of blood mononuclear cells from tuberculosis patients and sensitized healthy subjects. The response to the N-terminal peptide (residues 1 to 16) was found to be more frequent and stronger in tuberculosis patients. This finding is exceptional, considering that recognition of all other GroES peptides by patients was either diminished or not different from that of controls.

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页码：1645 / 1647

页数：3

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