Bioactivities of major constituents isolated from Angelica sinensis (Danggui)

被引：152

作者：

Chao, Wen-Wan ^{[1
]}

Lin, Bi-Fong ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Biochem Sci & Technol, Coll Life Sci, Taipei 10617, Taiwan

来源：

CHINESE MEDICINE | 2011年 / 6卷

关键词：

MACROPHAGE INFLAMMATORY PROTEIN-2; MEMBRANACEUS VAR. MONGHOLICUS; FERULIC ACID; IN-VITRO; Z-LIGUSTILIDE; ASTRAGALUS-MEMBRANACEUS; CHINESE HERBS; NITRIC-OXIDE; POLYSACCHARIDE FRACTIONS; PERITONEAL-MACROPHAGES;

D O I：

10.1186/1749-8546-6-29

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Danggui, also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects.

引用

页数：7

共 75 条

[1]

[Anonymous], 2004, Altern Med Rev, V9, P429

[2]

A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway [J].

Cao, W. ;

Li, X. -Q. ;

Wang, X. ;

Fan, H. -T. ;

Zhang, X. -N. ;

Hou, Y. ;

Liu, S. -B. ;

Mei, Q-B. .

PHYTOMEDICINE, 2010, 17 (8-9) :598-605

[3]

Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-κB trans-activation activity and LPS-induced inflammation [J].

Chao, Wen-Wan ;

Hong, Yong-Han ;

Chen, Miaw-Ling ;

Lin, Bi-Fong .

JOURNAL OF ETHNOPHARMACOLOGY, 2010, 129 (02) :244-249

[4]

The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions [J].

Chao, Wen-Wan ;

Kuo, Yueh-Hsiung ;

Li, Wei-Chu ;

Lin, Bi-Fong .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 122 (01) :68-75

[5]

Chao Wen-Wan, 2007, Taiwanese Journal of Agricultural Chemistry and Food Science, V45, P193

[6]

The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level [J].

Chen, M. P. ;

Yang, S. H. ;

Chou, C. H. ;

Yang, K. C. ;

Wu, C. C. ;

Cheng, Y. H. ;

Lin, Feng-Huei .

INFLAMMATION RESEARCH, 2010, 59 (08) :587-595

[7]

Cytotoxic constituents from Angelicae Sinensis Radix [J].

Chen, Quan Cheng ;

Lee, JongPill ;

Jin, Wen Yi ;

Youn, UiJoung ;

Kim, HongJin ;

Lee, Ik Soo ;

Zhang, XinFeng ;

Song, KyungSik ;

Seong, YeonHee ;

Bae, KiHwan .

ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (05) :565-569

[8]

Angelica stimulates proliferation of murine bone marrow mononuclear cells by the MAPK pathway [J].

Chen Xiaoping ;

Chen Jianghua ;

Ping, Zhang ;

Du Jizeng .

BLOOD CELLS MOLECULES AND DISEASES, 2006, 36 (03) :402-405

[9]

Assessment and comparison of immunoregulatory activity of four hydrosoluble fractions of Angelica sinensis in vitro on the peritoneal macrophages in ICR mice [J].

Chen, Ying ;

Duan, Jin-ao ;

Qian, Dawei ;

Guo, Jianming ;

Song, Bingsheng ;

Yang, Ming .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2010, 10 (04) :422-430

[10]

Estrogenic activity of standardized extract of Angelica sinensis [J].

Circosta, Clara ;

De Pasquale, Rita ;

Palumbo, Dora R. ;

Samperi, Stefania ;

Occhiuto, Francesco .

PHYTOTHERAPY RESEARCH, 2006, 20 (08) :665-669

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