Colchicine for epidermolysis bullosa acquisita

被引：61

作者：

Cunningham, BB

Kirchmann, TTT

Woodley, D

机构：

[1] NORTHWESTERN UNIV, SCH MED, DEPT DERMATOL, CHICAGO, IL 60611 USA

[2] STANFORD UNIV, SCH MED, DEPT DERMATOL, PALO ALTO, CA 94304 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1996年 / 34卷 / 05期

关键词：

D O I：

10.1016/S0190-9622(96)90013-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is difficult to treat. Recently one patient with severe EBA was described who responded dramatically to colchicine. Objective: Our purpose was to determine the efficacy of colchicine in the treatment of EBA. Methods: Four patients with severe EBA refractory to conventional therapy were treated with colchicine 0.6 to 1.5 mg a day for up to 4 years. Results: In all four patients the lessening of skin fragility and the decrease in spontaneous blister formation were dramatic; few side effects were noted. Conclusion: Colchicine should be considered in the treatment of EBA.

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收藏

页码：781 / 784

页数：4

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