The Role of p27Kip1 in Proteasome Inhibitor Induced Apoptosis

被引：31

作者：

Drexler, Hannes C. A. ^{[1
]}

机构：

[1] Max Planck Inst Physiol & Clin Res, Dept Mol Cell Biol, D-61231 Bad Nauheim, Germany

来源：

CELL CYCLE | 2003年 / 2卷 / 05期

关键词：

apoptosis; proteasome; cdk inhibitor; p27(Kip1); quiescence;

D O I：

10.4161/cc.2.5.461

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteasome inhibitors are potent inducers of cell death. The cytotoxic effect of proteasome inhibitors in general appears to be selective for proliferating cells, while quiescent cells seem to be protected. Conflicting results have been reported on the role of the CKI p27(Kip1) either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs. Here I discuss the role of p27(Kip1) in apoptosis and chemotherapy of cancer.

引用

页码：438 / 441

页数：4

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