Recent developments in the treatment of inflammatory bowel disease

被引：34

作者：

Rietdijk, Svend T. ^{[1
]}

D'Haens, Geert R. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1100 DE Amsterdam, Netherlands

来源：

JOURNAL OF DIGESTIVE DISEASES | 2013年 / 14卷 / 06期

关键词：

Crohn's disease; inflammatory bowel disease; natalizumab; tofacitinib; ulcerative colitis; ustekinumab; PLACEBO-CONTROLLED TRIAL; ACTIVE ULCERATIVE-COLITIS; CERTOLIZUMAB PEGOL; CROHNS-DISEASE; DOUBLE-BLIND; MAINTENANCE THERAPY; MONOCLONAL-ANTIBODY; HUMANIZED ANTIBODY; INDUCTION THERAPY; MMX MESALAMINE;

D O I：

10.1111/1751-2980.12048

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases that have been treated with corticosteroids, 5-aminosalicates and thiopurines, but therapeutic options have been broadened with the arrival of anti-tumor necrosis factor antibodies. In this article we reviewed the current evidence-based approach to inflammatory bowel disease, the modifications that have been made to existing therapies and discussed new drugs that have shown success in clinical trials. The new drugs discussed here are those that disturb lymphocyte homing to the gut (natalizumab, vedolizumab and anti-mucosal addressin cellular adhesion molecule); one that blocks interleukin (IL)-12 as well as the IL-23/T helper 17 (Th17) axis (ustekinumab) and one that blocks the signaling of multiple cytokines (tofacitinib).

引用

页码：282 / 287

页数：6

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