Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

被引:138
作者
Fier, Patrick S. [1 ]
Hartwig, John F. [1 ]
机构
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
关键词
carbenes; difluoromethylation; fluorine; one-pot reactions; phenols; ACID; REAGENT; ESTERS;
D O I
10.1002/anie.201209250
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The difluoromethylation of phenols with a simple, non-ozone-depleting reagent is described. The reaction occurs within minutes at room temperature with exceptional functional-group tolerance, which makes possible tandem processes for the conversion of arylboronic acids, aryl halides, and arenes to difluoromethyl ethers. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:2092 / 2095
页数:4
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