Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

被引：26

作者：

Raj, Vimal Master Sankar ^{[1
,2
]}

Alladin, Amanda ^{[2
]}

Pfeiffer, Brent ^{[3
]}

Katsoufis, Chryso ^{[1
]}

Defreitas, Marissa ^{[1
,2
]}

Edwards-Richards, Alicia ^{[1
,2
]}

Chandar, Jayanthi ^{[1
]}

Seeherunvong, Wacharee ^{[1
]}

McLaughlin, Gwenn ^{[3
]}

Zilleruelo, Gaston ^{[1
]}

Abitbol, Carolyn L. ^{[1
]}

机构：

[1] Univ Miami, Dept Pediat, Div Pediat Nephrol R714, Holtz Childrens Hosp,Jackson Hlth Syst, Miami, FL 33101 USA

[2] Univ Miami, Pediat Postgrad Training Program, Jackson Hlth Syst, Holtz Childrens Hosp, Miami, FL 33101 USA

[3] Univ Miami, Holtz Childrens Hosp, Jackson Hlth Syst, Miami, FL 33101 USA

来源：

PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 06期

关键词：

Therapeutic plasma exchange; Heat stroke; Continuous renal replacement therapy; LIVER-TRANSPLANTATION; MALIGNANT HYPERTHERMIA; ORGAN DYSFUNCTION; HEATSTROKE; ILLNESS; RHABDOMYOLYSIS; COAGULATION; PROGRESS; CARE;

D O I：

10.1007/s00467-013-2409-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. The addition of therapeutic plasma exchange using the PrismaflexA (R) system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

引用

页码：971 / 974

页数：4

共 20 条

[1] Fulminant hepatic failure from heat stroke requiring liver transplantation [J].