Dimeric Proanthocyanidins from the Roots of Ephedra sinica

被引：31

作者：

Tao, Huaming ^{[1
,2
]}

Wang, Lishu ^{[3
,4
]}

Cui, Zhanchen ^{[2
]}

Zhao, Daqing ^{[3
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

[2] Jilin Univ, Coll Chem, Changchun 130023, Peoples R China

[3] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China

[4] Jilin Prov Acad Chinese Med Sci, Changchun, Peoples R China

来源：

PLANTA MEDICA | 2008年 / 74卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Ephedra sinica Stapf; Ephedraceae; proanthocyanidins; ephedrannin B; mahuannin E; cytotoxicity;

D O I：

10.1055/s-0028-1088321

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new dimeric proanthocyanidins, ephedrannin B (2) and mahuannin E (4), along with two known congeners, ephedrannin A (1) and mahuannin D (3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new Compounds were deduced to be 5,7,4'-trihydroxyflavan-[4(alpha)-> 8,2(alpha)-> O -> 7]-kaempferol (2) and 5,7,4'-trihydroxyflavan-[4(beta)-> 8,2(beta)-> O -> 7]-epi-afzelechin (4). The compounds 1-4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.

引用

页码：1823 / 1825

页数：3

共 14 条

[1]

Ding Li-Li, 2006, Zhongguo Zhong Yao Za Zhi, V31, P1661

[2] STRUCTURE OF EPHEDRANNIN-A, A HYPOTENSIVE PRINCIPLE OF EPHEDRA ROOTS [J].