FLASH: A rapid method for prototyping paper-based microfluidic devices

被引：558

作者：

Martinez, Andres W. ^{[1
]}

Phillips, Scott T. ^{[1
]}

Wiley, Benjamin J. ^{[1
]}

Gupta, Malancha ^{[1
]}

Whitesides, George M. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

LAB ON A CHIP | 2008年 / 8卷 / 12期

关键词：

D O I：

10.1039/b811135a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of microfluidic devices in paper. Paper-based microfluidic devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 mu m in width and 70 mu m in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based microfluidic devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based microfluidic devices in regions where the technological support for conventional photolithography is not available.

引用

页码：2146 / 2150

页数：5

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