The dynamics of cyclin dependent kinase structure

被引：78

作者：

Morgan, DO

机构：

[1] Department of Physiology, Box 0444, University of California, San Francisco, CA 94143

来源：

CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(96)80076-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.

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页码：767 / 772

页数：6

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