c-Abl Kinase Is Required for β2 Integrin-Mediated Neutrophil Adhesion
被引:22
作者:
Cui, Lingling
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Cui, Lingling
[1
]
Chen, Cuixia
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
China Univ Petr E China, Ctr Bioengn & Biotechnol, Qingdao, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Chen, Cuixia
[1
,2
]
Xu, Ting
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Xu, Ting
[1
]
Zhang, Juechao
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Zhang, Juechao
[1
]
Shang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Shang, Xin
[1
]
Luo, Jixian
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Luo, Jixian
[1
]
Chen, Liang
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Chen, Liang
[1
]
Ba, Xueqing
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Ba, Xueqing
[1
]
Zeng, Xianlu
论文数: 0引用数: 0
h-index: 0
机构:
NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R ChinaNE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
Zeng, Xianlu
[1
]
机构:
[1] NE Normal Univ, Inst Cytol & Genet, Changchun 130024, Peoples R China
[2] China Univ Petr E China, Ctr Bioengn & Biotechnol, Qingdao, Peoples R China
Integrin regulation in neutrophil adhesion is essential for innate immune response. c-Abl kinase is a nonreceptor tyrosine kinase and is critical for signaling transduction from various receptors in leukocytes. Using neutrophils find dHL-60 (neutrophil-like differentiation of HL-60) cells, we show that c-Abl kinase is activated by beta(2) integrin engagement and is required for beta(2) integrin-dependent neutrophil sustained adhesion and spreading. The expression of beta(2) integrin on neutrophils induced by TNF-alpha is not affected by c-Abl kinase inhibitor STI571, suggesting that c-Abl kinase is not involved in TNF-alpha-induced integrin activation. The recruitment of c-Abl kinase to beta(2) integrin is dependent on talin head domain, which constitutively interacts with beta(2) integrin cytoplasmic domain. After activated, c-Abl kinase increases the tyrosine phosphorylation of Vav. The SH3 domain of c-Ahl kinase is involved in its interaction with talin and Vav. Thus, c-Abl kinase plays an essential role in the activation of Vav induced by beta(2), integrin ligation and in regulating neutrophil-sustained adhesion and spreading. The Journal of Immunology, 2009, 182: 3233-3242.