Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model

被引：157

作者：

Mubareka, Samira ^{[1
]}

Lowen, Anice C. ^{[1
]}

Steel, John ^{[1
]}

Coates, Allan L. ^{[4
,5
]}

Garcia-Sastre, Adolfo ^{[1
,2
,3
]}

Palese, Peter ^{[1
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Emerging Pathogens Inst, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[4] Univ Toronto, Div Resp Med, Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[5] Univ Toronto, Res Inst Physiol & Expt Med, Toronto, ON M5G 1X8, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 06期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; A VIRUS; UNITED-STATES; FERRET MODEL; INFECTIONS; SURVIVAL; TEMPERATURE; OUTBREAK; SPREAD; TRACT;

D O I：

10.1086/597073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Limited data on the relative contributions of different routes of transmission for influenza virus are available. Person-to-person transmission is central to seasonal and pandemic spread; nevertheless, the modes of spread are a matter of ongoing debate. Resolution of this discussion is paramount to the development of effective control measures in health care and community settings. Using the guinea pig model, we demonstrated that transmission of influenza A/Panama/2007/1999 (H3N2) virus through the air is efficient, compared with spread through contaminated environmental surfaces (fomites). We also examined the aerosol transmission efficiencies of 2 human influenza virus A strains and found that A/Panama/2007/1999 influenza virus transmitted more efficiently than A/Texas/36/1991 (H1N1) virus in our model. The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission.

引用

页码：858 / 865

页数：8

共 33 条

[1] SURVIVAL OF ENTERIC VIRUSES ON ENVIRONMENTAL FOMITES [J].

ABAD, FX ;

PINTO, RM ;

BOSCH, A .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (10) :3704-3710

[2]

ALFORD RH, 1966, P SOC EXP BIOL MED, V122, P800, DOI 10.3181/00379727-122-31255

[3]

Andrewes CH, 1941, BRIT J EXP PATHOL, V22, P91

[4]

[Anonymous], INT REC INF CONTR HL

[5]

BEAN B, 1982, J INFECT DIS, V146, P147

[6] STUDIES ON INFLUENZA IN THE PANDEMIC OF 1957-1958 .1. EPIDEMIOLOGIC, CLINICAL AND SEROLOGIC INVESTIGATION OF AN INTRAHOSPITAL EPIDEMIC, WITH A NOTE ON VACCINATION EFFICACY [J].

BLUMENFELD, HL ;

KILBOURNE, ED ;

LOURIA, DB ;

ROGERS, DE .

JOURNAL OF CLINICAL INVESTIGATION, 1959, 38 (01) :199-212

[7] The occurrence of influenza A virus on household and day care center fomites [J].

Boone, SA ;

Gerba, CP .

JOURNAL OF INFECTION, 2005, 51 (02) :103-109

[8] Development of respiratory syncytial virus "bronchiolitis" in guinea pigs does not reflect an allergic predisposition in the host [J].

Bramley, AM ;

Khan, MA ;

Manson, HE ;

Hegele, RG .

CHEST, 2003, 124 (02) :671-681

[9] Transmission of influenza A in human beings [J].

Brankston, Gabrielle ;

Gitterman, Leah ;

Hirji, Zahir ;

Lemieux, Camille ;

Gardam, Michael .

LANCET INFECTIOUS DISEASES, 2007, 7 (04) :257-265

[10] Transmission of influenza: Implications for control in health care settings [J].

Bridges, CB ;

Kuehnert, MJ ;

Hall, CB .

CLINICAL INFECTIOUS DISEASES, 2003, 37 (08) :1094-1101

← 1 2 3 4 →