Oxindole Synthesis by Direct Coupling of Csp2-H and Csp3-H Centers

被引：248

作者：

Jia, Yi-Xia ^{[1
]}

Kuendig, E. Peter ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 09期

关键词：

copper; oxidative coupling; oxindoles; radical reactions; C-H ACTIVATION; INTRAMOLECULAR ALPHA-ARYLATION; HETEROCYCLIC CARBENE LIGANDS; ENANTIOSELECTIVE SYNTHESIS; BOND FORMATION; CARBONYL-COMPOUNDS; HETEROAROMATIC-COMPOUNDS; SUBSTITUTED OXINDOLES; FUNCTIONALIZATION; AMIDES;

D O I：

10.1002/anie.200805652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An sp2/sp3 get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl Csp2-H and a Csp3-H center (see scheme; DMF = N,N-dimethylformamide). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1636 / 1639

页数：4

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