CYLD in ubiquitin signaling and tumor pathogenesis

被引：23

作者：

Ikeda, Fumiyo ^{[1
]}

Dikic, Ivan ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Sch Med, Inst Biochem 2, D-60590 Frankfurt, Germany

来源：

CELL | 2006年 / 125卷 / 04期

关键词：

D O I：

10.1016/j.cell.2006.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Absence of CYLD, which encodes a deubiquitinating enzyme, causes an inherited disease characterized by benign skin tumors. In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-kappa B and activates transcription of proliferation genes in response to growth signals.

引用

页码：643 / 645

页数：3

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