Insulin Resistance and Atherosclerosis

被引：108

作者：

Razani, Babak ^{[2
]}

Chakravarthy, Manu V. ^{[1
]}

Semenkovich, Clay F. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2008年 / 37卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ecl.2008.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance characterizes type 2 diabetes and the metabolic syndrome, disorders associated with an increased risk of death due to macrovascular disease. In the past few decades, research from both the basic science and clinical arenas has enabled evidence-based use of therapeutic modalities such as statins and angiotensin-converting enzyme inhibitors to reduce cardiovascular (CV) mortality in insulin-resistant patients. Recently, promising drugs such as the thiazolidinediones have come under scrutiny for possible deleterious CV effects. Ongoing research has broadened our understanding of the pathophysiology of atherosclerosis, implicating detrimental effects of inflammation and the cellular stress response on the vasculature. In this review, we address current thinking that is shaping our molecular understanding of insulin resistance and atherosclerosis.

引用

页码：603 / +

页数：20

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