Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure

被引：20

作者：

Xing, Yanqiu ^{[1
]}

Liu, Congcong ^{[1
,2
]}

Wang, Huanliang ^{[1
]}

Zhang, Xia ^{[1
,3
]}

Wang, Yan ^{[3
]}

Yue, Xizan ^{[1
]}

Li, Zhonggang ^{[1
]}

Wang, Xin ^{[4
]}

Zhang, Wenhua ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China

[2] Shandong Gen Police Hosp, Jinan, Shandong, Peoples R China

[3] Shandong Acad Med Sci, Jinan, Shandong, Peoples R China

[4] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

ARCHIVES OF MEDICAL RESEARCH | 2018年 / 49卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Nicorandil; Ischemic heart failure; LV remodeling; Bax;

D O I：

10.1016/j.arcmed.2018.12.006

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Nicorandil, the first clinically applied ATP-sensitive K+ channel (K(+)ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure and the potential mechanisms remain unclear. In this study, we investigated the effects of nicorandil on cardiac function, LV remodeling, and Bax expression in myocardium of LV in rats with ischemic heart failure. We found that nicorandil could improve not only the general condition, but also the cardiac function in rats with ischemic heart failure. The data also demonstrated that nicorandil reduced the hypertrophy and fibrosis of LV in rats with ischemic heart failure. Furthermore, nicorandil suppressed the protein level of Bax expression in LV myocardium. Taken together, these results suggest that nicorandil exerts its cardioprotective effect and improves LV remodeling in rats with ischemic heart failure. The mechanism might be relative to the inhibitory effect of nicorandil on the protein level of Bax expression in LV myocardium. (C) 2018 Published by Elsevier Inc. on behalf of IMSS.

引用

页码：583 / 587

页数：5

共 15 条

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Cardioprotective Effects of Nicorandil, a Mitochondrial Potassium Channel Opener against Doxorubicin-induced Cardiotoxicity in Rats [J].