Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions

被引:22
作者
Adighibe, O
Micklem, K
Campo, L
Ferguson, M
Harris, A
Pozos, R
Gatter, K
Pezzella, F [1 ]
机构
[1] Univ Oxford, John Radcliffe Hosp, Canc Res UK Tumour Pathol Grp, Nuffield Dept,Clin Lab Sci, Oxford OX3 9DU, England
[2] NIA, NIH, Lab Neurogenet, Bethesda, MD 20892 USA
[3] Churchill Hosp, Canc Res UK Med Oncol Unit, Oxford OX3 7LJ, England
[4] San Diego State Univ, San Diego, CA 92182 USA
[5] NIH, Minor Int Res Training Program, Div Int Training & Res, Fogarty Int Ctr, Bethesda, MD 20892 USA
关键词
lung cancer; angiogenesis; 3D reconstruction;
D O I
10.1038/sj.bjc.6603039
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-Dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.
引用
收藏
页码:1176 / 1179
页数:4
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