Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions

被引：22

作者：

Adighibe, O

Micklem, K

Campo, L

Ferguson, M

Harris, A

Pozos, R

Gatter, K

Pezzella, F ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Canc Res UK Tumour Pathol Grp, Nuffield Dept,Clin Lab Sci, Oxford OX3 9DU, England

[2] NIA, NIH, Lab Neurogenet, Bethesda, MD 20892 USA

[3] Churchill Hosp, Canc Res UK Med Oncol Unit, Oxford OX3 7LJ, England

[4] San Diego State Univ, San Diego, CA 92182 USA

[5] NIH, Minor Int Res Training Program, Div Int Training & Res, Fogarty Int Ctr, Bethesda, MD 20892 USA

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 94卷 / 08期

关键词：

lung cancer; angiogenesis; 3D reconstruction;

D O I：

10.1038/sj.bjc.6603039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-Dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity.

引用

页码：1176 / 1179

页数：4

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