Synaptic roles of Cdk5: Implications in higher cognitive functions and neurodegenerative diseases

被引：148

作者：

Cheung, ZH

Fu, AKY

Ip, NY ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Biotechnol Res Inst, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Mol Neurosci Ctr, Hong Kong, Hong Kong, Peoples R China

来源：

NEURON | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2006.02.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Accumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity.

引用

收藏

页码：13 / 18

页数：6

相关论文

共 37 条

[1] Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice:: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration [J].

Alarcón, JM ;

Malleret, G ;

Touzani, K ;

Vronskaya, S ;

Ishii, S ;

Kandel, ER ;

Barco, A .

NEURON, 2004, 42 (06) :947-959

[2] Role of Cdk5 in neuronal signaling, plasticity, and drug abuse [J].

Bibb, JA .

NEUROSIGNALS, 2003, 12 (4-5) :191-199

[3] Cdk5: A new player at synapses [J].

Cheng, K ;

Ip, NY .

NEUROSIGNALS, 2003, 12 (4-5) :180-190

[4] Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum [J].

Chergui, K ;

Svenningsson, P ;

Greengard, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :2191-2196

[5] Cdk5: mediator of neuronal death and survival [J].

Cheung, ZH ;

Ip, NY .

NEUROSCIENCE LETTERS, 2004, 361 (1-3) :47-51

[6] Cdk5 deregulation in the pathogenesis of Alzheimer's disease [J].

Cruz, JC ;

Tsai, LH .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (09) :452-458

[7] A decade of CDK5 [J].

Dhavan, R ;

Tsai, LH .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :749-759

[8] Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory [J].

Fischer, A ;

Sananbenesi, F ;

Pang, PT ;

Lu, B ;

Tsai, LH .

NEURON, 2005, 48 (05) :825-838

[9] Cdk5: A novel role in learning and memory [J].

Fischer, A ;

Sananbenesi, F ;

Spiess, J ;

Radulovic, J .

NEUROSIGNALS, 2003, 12 (4-5) :200-208

[10] Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number [J].

Flavell, SW ;

Cowan, CW ;

Kim, TK ;

Greer, PL ;

Lin, YX ;

Paradis, S ;

Griffith, EC ;

Hu, LS ;

Chen, CF ;

Greenberg, ME .

SCIENCE, 2006, 311 (5763) :1008-1012

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